Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1984-07-03
1988-07-26
Warren, Charles F.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435320, 435253, 536 27, 530309, 530324, 935 10, 935 13, 935 27, 935 73, C12N 1500, C12N 120, C07H 1512, C07K 710, C07K 730
Patent
active
047600233
ABSTRACT:
[21-Leucine] human urogastrone, hUG, comprising a polypeptide represented by the specified amino acid sequence has been found to be equivalent to the known hUG which has 21-Met and is disclosed together with its syntheses. Double-stranded polydeoxyribonucleotides comprising a structural gene for expressing the hUG, a recombinant plasmid comprising a structural gene for expressing the hUG, and E. coli transformed by the recombinant plasmid are also disclosed. Thanks to the substitution of Met in the known hUG by Leu, the peptide of hUG can now be produced by a conventional or typical method in which a genetically engineered precursor fused polypeptide is cleaved by cyanogen bromide at Met in the fused polypeptide.
REFERENCES:
Urdea et al., 1983, Proc. Natl. Acad. Sci., U.S.A., 80:7461-7465.
Stryer, L., 1975, pp. 18-19, In: Biochemistry, W. H. Freeman and Co.: San Francisco.
Smith et al., 1982, Chemical Synthesis and Cloning of a Gene for Human B-Urogastrone, Nucleic Acids Research 10 (15): 4467-4482.
Itakura et al., 1977, Expression in Eschenchia Coli of a Chemically Synthesized Gene for the Hormone Somatostatin, Science 198:1056-1063.
Banks et al., 1983-Chem. Abstr. 100 (21): #169364r.
Sumi et al., 1985, Chem. Abstr. 103 (9): #60035s.
Hasegawa Akira
Miyoshi Ken'ichi
Sumi Shinichiro
Suzuki Masanori
Fox David T.
Wakunaga Seiyaku Kabushiki Kaisha
Warren Charles F.
LandOfFree
[21-leucine] human urogastrone, corresponding gene, correspondin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with [21-leucine] human urogastrone, corresponding gene, correspondin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and [21-leucine] human urogastrone, corresponding gene, correspondin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-257765