Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2004-12-06
2009-12-01
McIntosh, III, Traviss C (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S046000, C514S047000, C514S048000
Reexamination Certificate
active
07625875
ABSTRACT:
2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
REFERENCES:
patent: 3074929 (1963-01-01), Hitchings et al.
patent: 3116282 (1963-12-01), Hunter
patent: 3480613 (1969-11-01), Walton
patent: 3798209 (1974-03-01), Wilkowski, et al.
patent: 3891623 (1975-06-01), Vorbruggen et al.
patent: 4022889 (1977-05-01), Bannister et al.
patent: 4058602 (1977-11-01), Beisler et al.
patent: RE29835 (1978-11-01), Witkowski et al.
patent: 4209613 (1980-06-01), Vorbruggen
patent: 4239753 (1980-12-01), Skulnick et al.
patent: 4294766 (1981-10-01), Schmidt et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4605659 (1986-08-01), Verheyden et al.
patent: 4689404 (1987-08-01), Kawada et al.
patent: 4754026 (1988-06-01), Kawada et al.
patent: 4814477 (1989-03-01), Wijnberg et al.
patent: 4880784 (1989-11-01), Robins et al.
patent: 4952740 (1990-08-01), Juge et al.
patent: 4957924 (1990-09-01), Beauchamp
patent: 5034394 (1991-07-01), Daluge
patent: 5122517 (1992-06-01), Vince et al.
patent: 5149794 (1992-09-01), Yatvin et al.
patent: 5157027 (1992-10-01), Biller et al.
patent: 5194654 (1993-03-01), Hostetler et al.
patent: 5200514 (1993-04-01), Chu
patent: 5223263 (1993-06-01), Hostetler et al.
patent: 5246924 (1993-09-01), Fox et al.
patent: 5256641 (1993-10-01), Yatvin et al.
patent: 5256797 (1993-10-01), Chou et al.
patent: 5322955 (1994-06-01), Matsumoto et al.
patent: 5371210 (1994-12-01), Chou et al.
patent: 5372808 (1994-12-01), Blatt et al.
patent: 5391769 (1995-02-01), Matsumoto et al.
patent: 5401861 (1995-03-01), Chou et al.
patent: 5411947 (1995-05-01), Hostetler et al.
patent: 5463092 (1995-10-01), Hostetler et al.
patent: 5539116 (1996-07-01), Liotta et al.
patent: 5543389 (1996-08-01), Yatvin et al.
patent: 5543390 (1996-08-01), Yatvin et al.
patent: 5543391 (1996-08-01), Yatvin et al.
patent: 5554728 (1996-09-01), Basava et al.
patent: 5565438 (1996-10-01), Chu et al.
patent: 5567688 (1996-10-01), Chu et al.
patent: 5587362 (1996-12-01), Chu et al.
patent: 5606048 (1997-02-01), Chou et al.
patent: 5676942 (1997-10-01), Testa et al.
patent: 5696277 (1997-12-01), Hostetler et al.
patent: 5738845 (1998-04-01), Imakawa
patent: 5744600 (1998-04-01), Mansuri et al.
patent: 5750676 (1998-05-01), Vorbruggen et al.
patent: 5763418 (1998-06-01), Matsuda et al.
patent: 5780617 (1998-07-01), Van den Bosch
patent: 5789608 (1998-08-01), Glazier
patent: 5821357 (1998-10-01), Chou et al.
patent: 5830455 (1998-11-01), Valtuena et al.
patent: 5849696 (1998-12-01), Chretien et al.
patent: 5908621 (1999-06-01), Glue et al.
patent: 5928636 (1999-07-01), Alber et al.
patent: 5942223 (1999-08-01), Bazer et al.
patent: 5977061 (1999-11-01), Holy et al.
patent: 5977325 (1999-11-01), McCarthy et al.
patent: 5980884 (1999-11-01), Blatt et al.
patent: 6002029 (1999-12-01), Hostetler et al.
patent: 6063628 (2000-05-01), Loeb et al.
patent: 6140310 (2000-10-01), Glazier
patent: 6153594 (2000-11-01), Børretzen et al.
patent: 6156501 (2000-12-01), McGall et al.
patent: 6172046 (2001-01-01), Albrecht
patent: 6248878 (2001-06-01), Matulic-Adamic et al.
patent: 6252060 (2001-06-01), Hostetler
patent: 6271212 (2001-08-01), Chu et al.
patent: 6277830 (2001-08-01), Ganguly et al.
patent: 6312662 (2001-11-01), Erion et al.
patent: 6316492 (2001-11-01), Young et al.
patent: 6340690 (2002-01-01), Bachand et al.
patent: 6348587 (2002-02-01), Schinazi et al.
patent: 6369040 (2002-04-01), Acevedo et al.
patent: 6395716 (2002-05-01), Gosselin et al.
patent: 6436437 (2002-08-01), Yatvin et al.
patent: 6444652 (2002-09-01), Gosselin et al.
patent: 6448392 (2002-09-01), Hostetler et al.
patent: 6455508 (2002-09-01), Ramasamy et al.
patent: 6458772 (2002-10-01), Zhou et al.
patent: 6458773 (2002-10-01), Gosselin et al.
patent: 6472373 (2002-10-01), Albrecht
patent: 6495677 (2002-12-01), Ramasamy et al.
patent: 6566344 (2003-05-01), Gosselin et al.
patent: 6566365 (2003-05-01), Storer et al.
patent: 6569837 (2003-05-01), Gosselin et al.
patent: 6573248 (2003-06-01), Ramasamy et al.
patent: 6596700 (2003-07-01), Sommadossi et al.
patent: 6599887 (2003-07-01), Hostetler et al.
patent: 6605614 (2003-08-01), Bachand et al.
patent: 6642206 (2003-11-01), Ramasamy et al.
patent: 6660721 (2003-12-01), Devos et al.
patent: 6748161 (2004-06-01), Ko et al.
patent: 6752981 (2004-06-01), Erion et al.
patent: 6777395 (2004-08-01), Bhat et al.
patent: 6784161 (2004-08-01), Ismaili et al.
patent: 6784166 (2004-08-01), Devos et al.
patent: 6787526 (2004-09-01), Bryant et al.
patent: 6812219 (2004-11-01), LaColla et al.
patent: 6815542 (2004-11-01), Hong et al.
patent: 6831069 (2004-12-01), Tam et al.
patent: 6833361 (2004-12-01), Hong et al.
patent: 6846810 (2005-01-01), Martin et al.
patent: 6875751 (2005-04-01), Imbach et al.
patent: 6908924 (2005-06-01), Watanabe et al.
patent: 6911424 (2005-06-01), Schinazi et al.
patent: 6914054 (2005-07-01), Sommadossi et al.
patent: 6924270 (2005-08-01), Ganguly et al.
patent: 6927291 (2005-08-01), Jin et al.
patent: 6946115 (2005-09-01), Erion et al.
patent: 6946450 (2005-09-01), Gosselin et al.
patent: 6949522 (2005-09-01), Otto et al.
patent: 6965033 (2005-11-01), Jiang et al.
patent: 7056895 (2006-06-01), Ramasamy et al.
patent: 7094770 (2006-08-01), Wantanabe et al.
patent: 7101861 (2006-09-01), Sommadossi et al.
patent: 7105493 (2006-09-01), Sommadossi et al.
patent: 7105499 (2006-09-01), Carroll et al.
patent: 7125855 (2006-10-01), Bhat et al.
patent: 7144868 (2006-12-01), Roberts et al.
patent: 7148206 (2006-12-01), Sommadossi et al.
patent: 7151089 (2006-12-01), Roberts et al.
patent: 7157434 (2007-01-01), Keicher et al.
patent: 7157441 (2007-01-01), Sommadossi et al.
patent: 7163929 (2007-01-01), Sommadossi et al.
patent: 7169766 (2007-01-01), Sommadossi et al.
patent: 7202224 (2007-04-01), Eldrup et al.
patent: 2002/0019363 (2002-02-01), Ismaili et al.
patent: 2002/0035085 (2002-03-01), Sommadossi et al.
patent: 2002/0052345 (2002-05-01), Erion et al.
patent: 2002/0055473 (2002-05-01), Ganguly et al.
patent: 2002/0055483 (2002-05-01), Watanabe et al.
patent: 2002/0095033 (2002-07-01), Ramasamy et al.
patent: 2002/0099072 (2002-07-01), Bachand et al.
patent: 2002/0127203 (2002-09-01), Albrecht
patent: 2002/0147160 (2002-10-01), Bhat et al.
patent: 2002/0156030 (2002-10-01), Ramasamy et al.
patent: 2002/0173490 (2002-11-01), Jiang et al.
patent: 2002/0198171 (2002-12-01), Schinazi et al.
patent: 2003/0008841 (2003-01-01), Devos et al.
patent: 2003/0028013 (2003-02-01), Hong et al.
patent: 2003/0039630 (2003-02-01), Albrecht
patent: 2003/0050229 (2003-03-01), LaColla et al.
patent: 2003/0053986 (2003-03-01), Zahm
patent: 2003/0055013 (2003-03-01), Brass
patent: 2003/0060400 (2003-03-01), LaColla et al.
patent: 2003/0083306 (2003-05-01), Imbach et al.
patent: 2003/0083307 (2003-05-01), Devos et al.
patent: 2003/0087873 (2003-05-01), Stuyver et al.
patent: 2003/0124512 (2003-07-01), Styuver
patent: 2003/0220290 (2003-11-01), Gosselin et al.
patent: 2003/0225028 (2003-12-01), Gosselin et al.
patent: 2003/0225029 (2003-12-01), Stuyver et al.
patent: 2003/0225037 (2003-12-01), Storer et al.
patent: 2003/0236216 (2003-12-01), Devos et al.
patent: 2004/0002476 (2004-01-01), Stuyver et al.
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Gosselin Gilles
LaColla Paola
Sommadossi Jean-Pierre
Storer Richard
Centre National de la Recherche Scientifique
Idenix Pharmaceuticals Inc.
Jones Day
L'Université Montpellier II
McIntosh, III Traviss C
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