2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxyl

Details 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxyl 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxyl

1987-01-05

1993-04-13

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544316, 544317, 544318, 514255, A61K 31495, C07D23922

Patent

active

052023303

ABSTRACT:
Pyrimidine compounds of the formula ##STR1## wherein X is sulfur or oxygen, Y is R.sub.11 or --O--R.sub.1, and R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents, particularly anti-hypertensive agents, due to their calcium entry blocking vasodilator activity.

REFERENCES:
patent: 4048171 (1977-09-01), Bossert et al.
patent: 4572908 (1966-02-01), Campbell et al.
patent: 4609494 (1986-09-01), Baldwin et al.
patent: 4640922 (1987-02-01), Cho et al.
patent: 4675321 (1987-06-01), Baldwin et al.
patent: 4683234 (1987-07-01), Cho et al.
patent: 4684655 (1987-08-01), Atwal
patent: 4684656 (1987-08-01), Atwal
patent: 4689414 (1987-08-01), Atwal
J. Org. Chem., vol. 50, pp. 4227-4230, Cho et al.--"Synthesis of Novel Dihydropyrimidines and Tetra-hydropyrimidines", (1978).
Khanina et al., Khim. Farm. Zh., vol. 12, pp. 1321-1322 (1978) "Synthesis and Pharmacological Investigation . . . ".
George et al., Synthesis (1975) pp. 405-407, "Condensed Heterocycles from 5-Ethoxycarbonyl-6-methyltetra hydropyrimidine-2-ones".
Sweet et al., J. Amer. Chem. Soc., vol. 95, pp. 8741-8749 (1973), "On the Synthesis of 3,4-Dihydro-2(1H)-pyrimidones . . . ".
Konyukhov et al., Zh. Organ. Khim., vol. 1, No. 8, pp. 1487-1489 (1965), "Synthesis and Investigation . . . ".
Folkers et al., J. Am. Chem. Soc., vol. 56, pp. 1374-1377, (1934) "Researches on Pyrimidines . . . ".
Goerlitzer et al., Arch. Pharm. vol. 314, pp. 938-949 (1981).
Burger, Medicinal Chemistry, 2nd Ed., 1960, pp. 551-564, 572-578, 582-591, 606-620.
Derwent, 87-15 2482/22, Apr. 22, 1987.
Elkasaby, Pakistan J.Sci.Ind.Res., vol. 21, No. 2, pp. 58-61 (1978), "Condensation of Ethyl .alpha.-Acetylcinnametes With Thioureas".
George et al., Synthesis (1975) pp. 405-407, Condensed Heterocycles from 5-Ethoxycarbonyl-6-methyltetrahydropyrimidin-2-ones.
Zidermane et al., "Antitumor Action of Dihydropyridine and Dihydropyrimidine Derivatives", Chem. Abst., 75, 47266e (1971).
Iwanami et al., "N-Substituted-1,4-Dihydropyridine Derivatives", Chem. Abst., 86, 43570d (1977).
Goerlitzer et al., Chem. Abst., 96, 85501u (1982).
Stolefuss, "Dihydropyrimidines Useful In Treating Circulatory Ailments" Chem. Abst. 101, 55110v (1984).
Merck Index, 10th Ed., "Nifedipine" 6374, (1983).
Bianchi et al., "Long Lasting Anti-hypertensive Effects . . . " IRCS Med. Sci., vol. 14, pp. 817-818 (1986).
Tamazawa et al., "Stereoselectivity of a Potent Calcium Antagonist . . . ", J. Med. Chem., vol. 29, pp. 2504-2511 (1986).
Goodman et al. The Pharmacological Basis of Therapeutics, 6 ed., p. 28.

Affiliated with

Also associated with

Rating

2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1155569