2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors...

Details 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors... 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors...

2008-08-15

2010-06-08

Badio, Barbara P (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

C514S178000, C514S179000, C552S502000, C552S625000, C568S326000

Reexamination Certificate

active

07732493

ABSTRACT:
The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula Iin whichR2means a C1-C8-alkyl group, a C1-C8-alkyloxy group or a halogen atom,R13means a hydrogen atom or a methyl group,R17means a hydrogen atom or a fluorine atom,as well as their pharmaceutically acceptable salts,their manufacture and use as medicaments for prophylaxis and therapy of estrogen-dependent diseases that can be influenced by inhibition of 17β-hydroxy steroid dehydro-genase type 1.

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Eliseev et al., “Synthesis of steroid estrogens 8-isoanalogs with a substituent at C-2.” Vestnik Leningradskogo Universiteta, Seriya 4: Fizika, Khimiya, No. 4, pp. 74-79, 1991. English Abstract.
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