2-substituted adenosines and 2-substituted adenosine 5'-carboxam

Details 2-substituted adenosines and 2-substituted adenosine 5'-carboxam 2-substituted adenosines and 2-substituted adenosine 5'-carboxam

1990-09-05

1994-01-18

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2722, 536 2761, A61K 3170, C07H 19167

Patent

active

052800156

ABSTRACT:
The present invention is directed to compounds useful as probes for characterizing and studying the adenosine A.sub.2 receptor. The present invention is also directed to methods of treating central nervous system disorders and cardiovascular disorders which include treating hypertension and thrombosis by administering said compounds.

REFERENCES:
Nikodijevic et al., FEBS Letters, 261(1), 67-70 (1990); Chem. Abstr., 112, p. 57, Abstr. No. 191,746m (1990); only CA Abstract. supplied.
Jacobson et al., J. Mol. Recognit., 2(4), 170-178 (1989); Chem. Abstr., 113, p. 380, Abstr. No. 148,304z (1990); only CA Abstract supplied.
Barrington et al., Proc. Nat. Acad. Sci. USA, 86, 6572-6576 (Sep. 1989).
Ramkumar et al., J. Clin. Invest., 82, 242-247 (1988).
R. P. Haugland, Handbook of Fluorescent Probes and Research Chemicals, 5th Ed., Molecular Probes, Inc., Eugene, Oreg., 1992, pp. 5-8.
Shai et al., ".sup.18 F-Labeled Insulin: A Prosthetic Group Methodology for Incorporation of a Positron Emitter into Peptides and Proteins," Biochemistry, 28(11), 4801-4806 (1989).

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