2-saccharinylmethyl heterocyclic carboxylates useful as proteoly

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548210, 546198, 544135, 544368, C07D41312, C07D41712

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active

056522541

ABSTRACT:
4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.

REFERENCES:
patent: 4782069 (1988-11-01), Sunkel et al.
patent: 5128339 (1992-07-01), Dunlap et al.
patent: 5187173 (1993-02-01), Desai et al.
patent: 5563163 (1996-10-01), Dunlap et al.

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