2-pyrazolin-5-ones

Details 2-pyrazolin-5-ones 2-pyrazolin-5-ones

2006-06-13

2006-06-13

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S238000, C544S333000, C544S371000, C544S405000, C548S364100

Reexamination Certificate

active

07060822

ABSTRACT:
Chemical compounds having structural formula Iand physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.

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