2-piperidinecarboxylic acid derivative, oncogene suppressor and

Details 2-piperidinecarboxylic acid derivative, oncogene suppressor and 2-piperidinecarboxylic acid derivative, oncogene suppressor and

1992-08-31

1994-08-02

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546297, C07D21176, C07D21186, C07D21188

Patent

active

053347234

ABSTRACT:
A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.

REFERENCES:
J. E. Baldwin et al., Tetrahedron Letters, 28 (31), 3605-3608 (1987).
J. K. Still, Tetrahedron Letters, 24 (41), 4405-4408 (1983).
R. K. Boeckman, Jr., Journal of American Chemical Society, 111, 8036-8037 (1989).
R. S. Garigipati, Tetrahedron Letters, 31 (14), 1969-1973 (1990).

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