2-iminopyrrolidine derivatives

Details 2-iminopyrrolidine derivatives 2-iminopyrrolidine derivatives

2007-07-17

2007-07-17

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S254090, C514S415000, C544S106000, C544S153000, C544S358000, C544S378000, C548S471000

Reexamination Certificate

active

10475188

ABSTRACT:
A 2-iminopyrrolidine derivative represented by the formula:{wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103represent hydrogen, halogen, C1-6alkyl, etc.; R5represents hydrogen, C1-6alkyl, C1-6alkoxy-C1-6alkyl, etc.; R6represents hydrogen, C1-6alkyl, C1-6alkyloxycarbonyl, etc.; Y1represents a single bond, —CH2—, etc.; Y2represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula:[wherein R10—R14represent hydrogen, C1-6alkyl, hydroxyl, C1-6alkoxy, etc.; and R11and R12or R12and R13may bond together to form a 5- to 8-membered heterocyclic ring], etc.},or a salt thereof.

REFERENCES:
patent: 3717648 (1973-02-01), Diana
patent: 3773788 (1973-11-01), Vis
patent: 3859302 (1975-01-01), Dixon
patent: 3887577 (1975-06-01), Dixon
patent: 3904395 (1975-09-01), Eilrich et al.
patent: 3920688 (1975-11-01), Eilrich et al.
patent: 3989709 (1976-11-01), White et al.
patent: 4004016 (1977-01-01), Yale et al.
patent: 4075342 (1978-02-01), Sale et al.
patent: 4118504 (1978-10-01), Giraldi et al.
patent: 4126613 (1978-11-01), Grisar et al.
patent: 4521793 (1985-06-01), Kabashima et al.
patent: 5143912 (1992-09-01), Burner et al.
patent: 5258387 (1993-11-01), Burner et al.
patent: 5362738 (1994-11-01), Burner et al.
patent: 5677322 (1997-10-01), Yasumura et al.
patent: 5935952 (1999-08-01), Todo et al.
patent: 5977134 (1999-11-01), Ciccarone et al.
patent: 6051718 (2000-04-01), Freyne et al.
patent: 6077320 (2000-06-01), Andrean
patent: 6087380 (2000-07-01), Hauel
patent: 6114532 (2000-09-01), Ries
patent: 6187799 (2001-02-01), Wood et al.
patent: 6194447 (2001-02-01), Jensen et al.
patent: 6376530 (2002-04-01), Claiborne et al.
patent: 2004/0004197 (2004-01-01), Sano
patent: 2004/0004204 (2004-01-01), Wang
patent: 2004/0242627 (2004-12-01), Suzuki et al.
patent: 2004/0254376 (2004-12-01), Suzuki et al.
patent: 2005/0004197 (2005-01-01), Suzuki et al.
patent: 2005/0245592 (2005-11-01), Suzuki et al.
patent: 2003825 (1970-12-01), None
patent: 2154525 (1972-06-01), None
patent: 2551868 (1976-08-01), None
patent: 364204 (1989-10-01), None
patent: 638075 (1994-02-01), None
patent: 842161 (1996-07-01), None
patent: 934280 (1997-09-01), None
patent: 847749 (1998-06-01), None
patent: 1091942 (1999-07-01), None
patent: 1176141 (2000-03-01), None
patent: 1295478 (1972-11-01), None
patent: 1344663 (1974-01-01), None
patent: 48-42875 (1973-06-01), None
patent: S51-22720 (1976-02-01), None
patent: S51-125071 (1976-11-01), None
patent: 53-71063 (1978-06-01), None
patent: 62-22760 (1987-01-01), None
patent: 12-503678 (1989-10-01), None
patent: 4-244083 (1990-08-01), None
patent: 3-50555 (1991-03-01), None
patent: 4-504709 (1992-08-01), None
patent: H07-32103 (1995-02-01), None
patent: H08-225753 (1996-09-01), None
patent: 9-40643 (1997-02-01), None
patent: 10-167965 (1998-06-01), None
patent: 10-509150 (1998-09-01), None
patent: 11-509191 (1999-08-01), None
patent: 2002-155060 (2002-06-01), None
patent: WO 83/02920 (1983-09-01), None
patent: WO 96/05192 (1996-02-01), None
patent: WO 96/14844 (1996-05-01), None
patent: WO 98/00408 (1998-01-01), None
patent: WO 98/37075 (1998-08-01), None
patent: WO 99/26943 (1999-06-01), None
patent: WO 99/40072 (1999-08-01), None
patent: WO 00/01676 (2000-01-01), None
patent: WO 00/53582 (2000-09-01), None
patent: WO 00/67755 (2000-11-01), None
Kovtunenko et al; 5H-Imidazo[2,1-a]isoindole derivatives; 1985; Ukrainskii Khimicheskii Zhurnal; vol. 51; Issue 6; pp. 644-649.
Kovtunenko et al; 1-imino-2-alkylacylisoindoles; 1984; Ukrainskii Khimicheskii Zhurnal; vol. 50; Issue 10; pp. 1105-1110.
Settimo et al., II Farmaco, 49(12), 829-834 (1994).
Settimo et al., II Farmaco, 47(10), 1293-1313, 1992.
Kigasawa et al., J. Het. Chem., 15, 369 (1978).
Rehse et al., Arch. Pharm. (Weinheim) 328, 77-80 (1995); Chackalamannil et al., Bio. Med. Chem. Let. 11 (2001) 2851-2853.
Kovtunenko, et al (5H-Imidazo[2,1-a]isoindole derivatives; 1985; Ukrainskii Khimicheskii Zhurnal; vol. 51; Issue 6; pp. 644-649) and (1-imino-2-alkylacylisoindolines; 1984; Ukrainskii Zhurnal; vol. 50; Issue 10; pp. 1105-1110.
Chemical Abstracts, vol. 127, abs.No. 81319.
Z.Naturforsch., B:Chemical Sci., (1996), 51(12), p. 1791-810.
Bulletin Soc.Chim.Belg., (1992), 101(6), p. 509-12.
Khim.Geterotsikl.Soedin., (1987), (9), p. 1264-9.
Vest.Kiev.Un-ta.Khimiya, (1985), (26), p. 21-5.
Ukr.Khim.Zh., (1985), 51(6), p. 644-9.
Arch Pharm., (1985), 318(8), p. 735-43.
Chemical Abstracts, vol. 103, abs.No. 104932.
Ukr.Khim.Zh., (1984), 50(11), p. 1198-203.
Chemical Abstracts, vol. 102, abs.No. 220805.
Ukr.Khim.Zh., (1984), 50(10), p. 1105-10.
Ukr.Khim.Zh., (1984), 50(5), p. 530-4.
Ukr.Khim.Zh., (1981), 47(7), p. 735-8.
Ukr.Khim.Zh., (1981), 47(3), p. 291-5.
J.Heterocycl.Chem., (1978), 15(3), p. 369-75.
Arch.Pharm., (1976), 309(5), p. 356-66.
Z.Naturforsch., Teil B, (1973), 28(11-12), p. 801-4.
Arzneim.-Forsch., (1973), 23(8), p. 1090-100.
Chemical Abstracts, vol. 76, abs.No. 153482.
Chemical Abstracts, vol. 72, abs.No. 132428.
Chemical Abstracts, vol. 53, abs.No. 16106c-16107d.
Chemical Abstracts, vol. 53, abs.No. 15082h-15085d.
Babichev, F.S., et al., “Structure Of Reaction Products Of 1-Amino-3H-Isoindole With Benzyl Chloride And .Alpha.-Bromoketones,”Ukrainskii Khimicheskii Zhurnal, 50(6): 623-626, 1984. (Abstract).
Lessel, J., “Benzodiazepine Und Isoindole Durch Acylierung Von Amidinen Benzodiazepines And Isoindoles By Acylation Of Amidines,”Pharmazie, 48(11): 812-816, 1993.
May, et al., “Chemie Und Biologische Eigenschaften Substituierter 3-Amino-1H-Isoindole,”Arzneim.-Forsch, 30(11): 1487-1493, 1980.
O'Sullivan, R.D. and Parkins, A.W., “The Synthesis Of N-Heterocycles Using Ortho-Metallated Primary Benzylamine Complexes Of Palladium And Platinum,”J. Chem. Soc., Chem. Commun., 17: 1165-1166, 1984.
“Oxazines And Thiazines,”Chemical Abstracts, 78: 478, 1973. (Abstract No. 111229).
Toja, E., et al., Synthesis And Pregnancy Terminating Activity Of 2-Arylimidazo ′2, 1-a!
Isoquinolines And Isoindoles,Arzneim.-Forsch, 33(11): 1222-6, 1983.
Sawanishi, H., et al., “Studies On Diazepines. XXI. Photochemical Synthesis Of 1H-2,4-Benzodiazepines From 4-Azidoisoquinolines,”Chem. Pharm. Bull., 33(10): 4564-4571, 1985.
Sawanish, H. and Tsuchiya, T., “Synthesis And Characterization Of 1H-2, 4-Benzodiazepines,”Heterocycles, 22(12): 2725-2728, 1984.
Ahn, et al., “Structure-Activity Relationships of Pyrroloquinazolines as Thrombin Receptor Antagonists”,Bioorganic&Medicinal Chemistry Letters, 9: 2073-2078, 1999.
Ahn, et al., “Inhibition of Cellular Action of Thrombin by N3-Cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a Nonpeptide Thrombin Receptor Antagonist,”Biochem. Pharm., 60: 1425-1434, 2000.
Alfaia, et al., “Quaternization Reaction of Heterocyclic Imines in Methanol—A Case of Strong Anti-Reactivity Selectivity Principle with Isoselective Temperature”,European Journal of Organic Chemistry, 3627-3631, 2000.
Andrade-Gordon, et al., “Design, Synthesis, and Biological Characteriation of a Peptide-mimetic Antagonist for a Tethered-ligand Receptor,”PNAS, 96: 12257-12262, 1999.
Anisimova, et al., “Imidazo [1, 2-a] Benzimidazole Derivatives. X. Nitration of 2, 9-Disubstituted Imidazo [1, 2-a] Benzimidazole,”Khim. Geterotsikl. Soedin, 2: 258-262, 1975.
Anisimova, et al., “Imidazo [1, 2-a] Benzimidazole Derivatives. 22. Synthesis of 2, 3-dihydroimidazo [1, 2-a]benzimidazoles from 3-(2-hydroxyethyl)-2-iminobenzimidazolines,”Khim. Geterotsikl. Soedin, 7: 918-925, 1986.
Anisimova, et al., “Imidazo [1, 2-a] Benzimidazole Derivatives. 25. Reaction of 2, 9-disubstituted Imidazo [1, 2-a]benzimidazoles With Acrylic Acids and Their Derivatives,”Khim. Geterotsikl. Soedin, 11: 1496-1502, 1987.
Babchiev, et al., “The Structure of the Salts of 2-amino.DELTA.1-pyrroline with Benzyl Chloride and

Affiliated with

Also associated with

Rating

2-iminopyrrolidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-iminopyrrolidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-iminopyrrolidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3785979