Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-02-12
1993-03-30
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31495, A61K 3150
Patent
active
051984423
ABSTRACT:
A compound selected from the group consisting of those having the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.4 are independently selected from the group consisting of H and alkyl radicals having 1 to 4 carbon atoms; the R.sub.2 s are each of H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo; the R.sub.3 s are each H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo, provided that the R.sub.2 s or the R.sub.3 s are alkyl radicals; the 2-imidazolin-2-ylamino group may be in any of the 5-, 6, 7- or 8-positions of the quinoxaline nucleus; and R.sub.5, R.sub.6 and R.sub.7 each is located in one of the remaining 5-, 6-, 7- or 8- positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals having 1 to 3 carbon atoms. Such compounds, when administered to a mammal, provide desired thereapeutic effects, such as alternation in the rate of fluid transport in the gastrointestianl tract, reduction in intraocular pressure, and increase in renal fluid flow.
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Allergan Inc.
Henley III Raymond J.
Uxa Frank J.
Waddell Frederick E.
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