Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-13
1996-04-02
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514267, 514362, 514364, 514368, 514397, 514399, 544251, 544284, 544287, 548126, 548178, 548179, 5483061, 5483101, A61K 3154, A61K 31535, C07D23986, C07D23512
Patent
active
055040896
ABSTRACT:
Compounds of formula I ##STR1## wherein R.sup.1 -R.sup.4, X, Y, and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful as potassium channel openers for the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
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P. P. Righetti et al., "Changes in the Reactivity of 2-Oxoindolin-3-Ylidene Derivatives with Ethylvinylether Induced by Electron-Withdrawing Groups. The Importance of the Lumo Coefficients", Tetrahedron, (1981), 37, 1779-1785.
Jeffrey J. Morris et al., "Non-Steroidal Antiandrogens. Design of Novel Compounds Based on an Infrared Study of the Dominant Conformation and Hydrogen-Bonding Properties of a Series of Anilide Antiandrogens, " J. Med. Chem., (1991), 34, 447-455.
I. Tamm et al., Structural Requirements of Selective Inhibition of Enteroviruses by 2-(.alpha.-Hydroxybenzyl-benzimidazole and Related Compounds, Nature, 223, 785-88, 1969.
Grumbling Matthew V.
Hohenschutz Liza D.
Zeneca Limited
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