2-Halo-6-O-substituted ketolide derivatives

Details 2-Halo-6-O-substituted ketolide derivatives 2-Halo-6-O-substituted ketolide derivatives

1998-09-16

2000-09-26

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 536 73, 536 74, A61K 3170, C07H 1708

Patent

active

061242691

ABSTRACT:
Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

REFERENCES:
patent: 4990602 (1991-02-01), Morimoto et al.
patent: 5403923 (1995-04-01), Kashimura et al.
patent: 5444051 (1995-08-01), Agouridas et al.
patent: 5631355 (1997-05-01), Asaka et al.
patent: 5747467 (1998-05-01), Agouridas et al.
patent: 5866549 (1999-02-01), Or et al.
Journal of Antibiotics, vol. 43, No. 3 (Mar. 1990), pp. 286-294, Morimoto et al., "Chemical Modification of Erythromycins: II. Synthesis and Antibacterial Activity of O-Alkyl Derivatives of Erythromycin A".
Journal of Antibiotics, vol. 37, No. 2 (Feb. 1984), pp. 187-189, Morimoto, et al., "Chemical Modifications of Erythromycins: I. Synthesis and Antibacterial Activity of 6-O-Methylerythromycins A".

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