2-amino—5-substituted pyrimidine inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S330000, C514S272000, C514S275000

Reexamination Certificate

active

08030487

ABSTRACT:
Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.

REFERENCES:
patent: 6378526 (2002-04-01), Bowman et al.
patent: 7528143 (2009-05-01), Noronha et al.
patent: 2003/0134838 (2003-07-01), Bornemann et al.
patent: 2004/0106615 (2004-06-01), Cochran et al.
patent: 2004/0167198 (2004-08-01), Wrasidlo et al.
patent: 2005/0234083 (2005-10-01), Chamberlain et al.
patent: 2005/0239852 (2005-10-01), Ciufolini et al.
patent: 2006/0247250 (2006-11-01), Cao et al.
patent: 2006/0292203 (2006-12-01), Dellamary et al.
patent: 2007/0072862 (2007-03-01), Dimauro et al.
patent: 2007/0149508 (2007-06-01), Noronha et al.
patent: 2007/0161615 (2007-07-01), Andrews et al.
patent: WO 0046203 (2000-08-01), None
patent: WO-02/064096 (2002-08-01), None
patent: WO-02/064096 (2002-08-01), None
patent: WO-03/066601 (2003-08-01), None
patent: WO-2006/101977 (2006-09-01), None
patent: WO-2006/101977 (2006-09-01), None
patent: WO-2006/133411 (2006-12-01), None
patent: WO-2007/056023 (2007-05-01), None
patent: WO-2007/056023 (2007-05-01), None
patent: WO-2007/056075 (2007-05-01), None
patent: WO-2007/056075 (2007-05-01), None
patent: WO-2008/008234 (2008-01-01), None
Mass, R. D., Int. J. Radiation Oncology Bio. Phys.vol. 58(3): 932-940, 2004.
Fabbro et al. Pharmacology & therapeutics 93, 79-98, 2002.
Cohen et al., Current Opinion in Chemical Biology, 3,459-465, 1999.
Freshney et al.,Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4.
Dermer et al., Bio/Technology, 1994, 12:320.
Powell et al., British Journal of Dermatology, 141″ 802-810, 1999.
Golub et al., Science, 286, 531-537, 1999.
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
Wolff Manfred E. “Burger's Medicinal Chemistry, 5ed, Part 1”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutices, 3ed.”, Marcel Dekker, New York. 1996, pp. 451 and 596.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
Krause, D. S. et al. (Jul. 14, 2005). “Tyrosine Kinases as Targets for Cancer Therapy,”N. Eng. J. Med.353(2):172-187.
Shah, N. P. et al. (Jul. 16, 2004). “Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor,”Science305:399-401.
International Search Report mailed on Sep. 21, 2006, for PCT Patent Application No. PCT/US06/009518, filed on Mar. 15, 2006, 2 pages.
Written Opinion mailed on Sep. 21, 2006, for PCT Patent Application No. PCT/US06/009518, filed on Mar. 15, 2006, 4 pages.
International Search Report mailed on Sep. 18, 2006, on for PCT Patent Application No. PCT/US06/022480, filed on Jun. 7, 2006, one page.
Written Opinion mailed on Sep. 18, 2006, for PCT Patent Application No. PCT/US06/022480, filed on Jun. 7, 2006, 3 pages.
International Search Report mailed on Jul. 25, 2007, for PCT Patent Application No. PCT/US06/42838, filed on Oct. 31, 2006, 2 pages.
Written Opinion mailed on Jul. 25, 2007, for PCT Patent Application No. PCT/US06/42838, filed on Oct. 31, 2006, 4 pages.
International Search Report mailed on Jul. 30, 2007, for PCT Patent Application No. PCT/US06/042697, filed Oct. 31, 2006, 2 pages.
Written Opinion mailed on mailed on Jul. 30, 2007, for PCT Patent Application No. PCT/US06/042697, filed Oct. 31, 2006, 4 pages.
International Search Report mailed on Dec. 4, 2007, for PCT Patent Application No. PCT/US07/15357, filed on Jul. 2, 2007, 2 pages.
Written Opinion mailed on Dec. 4, 2007, for PCT Patent Application No. PCT/US07/15357, filed on Jul. 2, 2007, 6 pages.
Non Final Office Action issued on Jan. 12, 2009, for U.S. Appl. No. 11/377,234, filed Mar. 15, 2006, 6 pages.
Non Final Office Action issued on Jul. 23, 2008, for U.S. Appl. No. 11/377,234, filed Mar. 15, 2006, 23 pages.
Non Final Office Action issued Dec. 22, 2008, for U.S. Appl. No. 11/591,252 filed Oct. 31, 2006, 20 pages.
Non Final Office Action issued Jun. 23, 2008, for U.S. Appl. No. 11/591,252 filed Oct. 31, 2006, 21 pages.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2-amino—5-substituted pyrimidine inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-amino—5-substituted pyrimidine inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-amino—5-substituted pyrimidine inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4297574

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.