2-(amino-substituted)-4-aryl pyrimidines and related...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S252140, C514S275000, C544S122000, C544S295000, C544S330000, C544S331000, C544S332000

Reexamination Certificate

active

07732444

ABSTRACT:
A heterocyclic inhibitor having the formula I, with the variables defined herein, which is useful for treating inflammatory and other physiological disorders in which PKC-theta isoform plays a role:

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“4-Pyrimidinecarboxamide, 6-(4-methoxyphenyl)-2-[(2-phenylethyl)amino]-(CA Index Name),” CAS Registry No. 552284-37-4, entered Jul. 22, 2003.
“2-Pyrimidinamine, 4-(4-methoxyphenyl)-N-[2-(2-pyridinyl)ethyl]-(CA Index Name),” CAS Registry No. 667895-75-2, entered Mar. 26, 2004.
“1H-Indole-3-ethanamine, N-[4-(4-methoxyphenyl)-2-pyrimidinyl]-(CA Index Name),” CAS Registry No. 682790-41-6, entered May 18, 2004.
“2-Pyrimidinamine, 4-(4-methoxyphenyl)-N-(2-phenylethyl)-(CA Index Name),” CAS Registry No. 682792-99-0, entered May 18, 2004.
“2-Pyrimidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-4-(4-methoxyphenyl)-(CA Index Name),” CAS Registry No. 682793-00-6, entered May 18, 2004.
“2-Pyrimidinamine, N-[2-(4-fluorophenyl)ethyl]-4-(4-methoxyphenyl)-(CA Index Name),” CAS Registry No. 682793-39-1, entered May 18, 2004.
“2-Pyrimidinamine, N-[2-(3,4-dimethoxyphenyl)ethyl]-4-(4-methoxyphenyl)-(CA Index Name),” CAS Registry No. 682793-40-4, entered May 18, 2004.
“1H-Indole-3-ethanamine, N-[4-(2,4-dimethoxyphenyl)-2-pyrimidinyl]-(CA Index Name),” CAS Registry No. 682795-07-9, entered May 18, 2004.
“2-Pyrimidinamine, 4-(2,4-dimethoxyphenyl)-N-(2-phenylethyl)-(CA Index Name),” CAS Registry No. 682795-16-0, entered May 18, 2004.
“2-Pyrimidinamine, 4-(2,4-dimethoxyphenyl)-N-[2-(2-pyridinypethyl]-(CA Index Name),” CAS Registry No. 682795-19-3, entered May 18, 2004.
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“2-Pyrimidinamine, 4-(2,4-dimethoxyphenyl)-N-[2-(4-fluorophenyl)ethyl]-(CA Index Name),” CAS Registry No. 682795-85-3, entered May 18, 2004.
“2-Pyrimidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-4-(2,4-dimethoxyphenyl)-(CA Index Name),” CAS Registry No. 682797-30-4, entered May 18, 2004.
“2-Pyrimidinamine, N-[2-(3,4-dimethoxyphenyl)ethyl]-4-(4-methoxyphenyl)-6-(trifluoromethyl)-(CA Index Name),” CAS Registry No. 686725-15-5, entered May 28, 2004.
“2-Pyrimidinamine, 4-(3-methoxyphenyl)-N-(2-phenylethyl)-6-(trifluoromethyl)-(CA Index Name),” CAS Registry No. 686725-36-0, entered May 28, 2004.
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“2-Pyrimidinamine, 4-(3,4-dimethoxypheny1)-N-(2-phenylethyl)-6-(trifluoromethyl)-(CA Index Name),” CAS Registry No. 686725-47-3, entered May 28, 2004.
“2-Pyrimidinamine, 4-(3,4-dimethoxypheny1)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6-(trifluoromethyl)-(CA Index Name),” CAS Registry No. 686725-48-4, entered May 28, 2004.
“2-Pyrimidinamine, 4-(4-methoxyphenyl)-N-(2-phenylethyl)-6-(trifluoromethyl)-(CA Index Name),” CAS Registry No. 725695-31-8, entered Aug. 12, 2004.

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