2-alkylpyrrolidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514425, 514866, A61K 3140

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active

058542728

ABSTRACT:
The present invention relates to (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine and other substituted 2-methylpyrrolidines and their use for the treatment of diabetes.

REFERENCES:
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patent: 4973602 (1990-11-01), Koszyk et al.
Nash et al., Phytochemistry, vol. 24, No. 7, pp. 1620-1622 (1985).
Furukawa et al., Phytochemistry, vol. 24, No. 3, pp. 593-594 (1985).
Hung et al., J. Org. Chem, vol. 56, pp. 3849-3855 (1991).
Setoi et al., Chem. Pharm. Bull, vol. 35, pp. 3995-3999 (1987).
Fleet et al., Tetrahedron, vol. 42, pp. 5685-5692 (1986).
Fleet et al., Tetrahedron, vol. 44, pp. 2649-2655 (1988).
Fleet et al., Tetrahedron, vol. 26, No. 26, pp. 3127-3130 (1985).
Abstract of JP 61171465 (1986).

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