Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-09-08
1998-02-17
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514213, 514221, 5142242, 5142305, 514249, 514259, 514315, 514311, 514399, 544 52, 544105, 544253, 544283, 544355, 546175, 546168, 546245, 546246, 548491, 548493, 5483094, 5483097, 540593, A61K 3154, A61K 31535, C07D41302, C07D41102
Patent
active
057191417
ABSTRACT:
Compounds of the formula I ##STR1## in which R.sub.1 is arylamino, N-aryl-N-(lower alkoxy-lower alkyl)-amino, N-aryl-N-aryl-lower alkyl-amino or heterocyclyl bonded via a ring carbon atom, X is a carbonyl or methylene group, R.sub.2 and R.sub.3 independently of one another are hydrogen or lower alkyl or, together with the carbon atom with which they are bonded, are a cycloalkylidene radical, R.sub.4 is hydrogen, lower alkyl, lower alkanoyl or lower alkoxycarbonyl, R.sub.5 is hydroxyl, lower alkanoyloxy or lower alkoxycarbonyloxy, R.sub.6 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl-lower alkyl, aryl-lower alkyl or heteroaryl-lower alkyl having 5 to 7 ring atoms in the heteroaryl ring and R.sub.7 is hydrogen or lower alkyl, or R.sub.6 and R.sub.7, together with the carbon atom with which they are bonded, are a cydoalkylidene radical and R.sub.8 denotes an aliphatic, cycloaliphatic-aliphatic or heteroarylaliphatic radical, and their salts can be used as active ingredients for medicaments for treatment of high blood pressure.
REFERENCES:
patent: 4613676 (1986-09-01), Fuhrer et al.
patent: 4898877 (1990-02-01), Meyer et al.
patent: 5409925 (1995-04-01), Hanson et al.
patent: 5411961 (1995-05-01), Hanson et al.
patent: 5411962 (1995-05-01), Hanson et al.
patent: 5420126 (1995-05-01), Matsumoto et al.
patent: 5440035 (1995-08-01), Bernstein et al.
patent: 5496815 (1996-03-01), Ozeki et al.
Plummer, Mark et al., Bioorganic & Medicinal Chemistry Letters, vol. 3, pp. 2119-2124 (1993).
Hanessian, Stephen et al. Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1696-1702 (1994).
Tetrahedron Letters, vol. 30, pp. 3845-3849 (1989). Bradbury et al.
Tetrahedron Letters, vol. 31, pp. 1803-1806 (1990).
Tetrahedron Letters, vol. 32, pp. 3985-3988, (1991).
Bradbury, Robert et al., J. Med. Chem. vol. 33, pp. 2335-2342 (1990).
Journal of Organic Chemistry, vol. 51, pp. 4828-4833 (1986).
Cohen Nissim Claude
Grutter Markus
Mah Robert
Maibaum Jurgen Klaus
Rasetti Vittorio
Ferraro Gregory D.
Grumbling Matthew V.
Mathias Marla J.
Novartis Corporation
LandOfFree
2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid ami does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid ami, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid ami will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1784120