2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides

Details 2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides 2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides

1992-08-05

1994-02-22

Hollrah, Glennon R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142242, 5142305, 514299, 514304, 514320, 544 47, 544105, 546112, 546126, 546133, 546196, 546354, 546355, 546386, A61K 3155, C07D45302

Patent

active

052887316

ABSTRACT:
Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT.sub.3 -antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any significant D.sub.2 receptor binding affinity, therapeutic compositions and methods of treatment of disorders which result from 5-HT.sub.3 activity using said compounds. Processes for their preparation and the preparation of their intermediates are also disclosed.

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patent: 4924010 (1990-05-01), Youssefyeh et al.
patent: 4959485 (1990-09-01), Youssefyeh et al.

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