2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5142242, 5142305, 514299, 514304, 514320, 544 47, 544105, 546112, 546126, 546133, 546196, 546354, 546355, 546386, A61K 3155, C07D45302

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active

052887316

ABSTRACT:
Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT.sub.3 -antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any significant D.sub.2 receptor binding affinity, therapeutic compositions and methods of treatment of disorders which result from 5-HT.sub.3 activity using said compounds. Processes for their preparation and the preparation of their intermediates are also disclosed.

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