(2-5')-Oligo (3'-deoxyadenylate) and derivatives thereof

Details (2-5')-Oligo (3'-deoxyadenylate) and derivatives thereof (2-5')-Oligo (3'-deoxyadenylate) and derivatives thereof

1985-03-29

1987-11-24

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 90, 435194, C12P 1934, C12P 1936, C12N 912

Patent

active

047089350

ABSTRACT:
3'-deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double straded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes Simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.

REFERENCES:
patent: 2472130 (1949-06-01), Szent-Gyorgyi
patent: 3299043 (1967-01-01), Schramm et al.
patent: 3337530 (1967-08-01), Hanze
patent: 4000260 (1976-12-01), Prusoff et al.
patent: 4210746 (1980-07-01), Kerr et al.
patent: 4315001 (1982-02-01), Blough
patent: 4378352 (1983-03-01), Kimchi et al.

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