2,5-dioxopiperazine compounds and method for preparing .alpha.-a

Details 2,5-dioxopiperazine compounds and method for preparing .alpha.-a 2,5-dioxopiperazine compounds and method for preparing .alpha.-a

1992-10-23

1994-03-15

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

560 40, 560 41, C07D24104, C07C22900

Patent

active

052947149

ABSTRACT:
A method of preparing .alpha.-APM derivatives without using an expensive L-phenylalanine is provided, wherein 2,5-dioxopiperazine-3-acetamide is reacted with acetic anhydride to give N,N'-diacetyl-6-cyanomethyl-2,5-dioxopiperazine, which is then reacted with benzaldehyde in the presence of a strong base to give 1-acetyl-3-benzylidene-6-cyanomethyl-2,5-dioxopiperazine. This is treated with hydrazine to give 3-benzylidene-6-cyanomethyl-2,5-dioxopiperazine, which is then reduced to prepare 3-benzyl-6-cyanomethyl-2,5-dioxopiperazine, which is converted by reaction with methanol in the presence of a strong acid to an .alpha.-APM derivative for use as a sweetener.

REFERENCES:
patent: 4579747 (1986-04-01), Sugiyama
patent: 4673744 (1987-06-01), Hisamitsu et al.
patent: 4745210 (1988-05-01), Mita et al.
patent: 4760164 (1988-07-01), Park et al.
patent: 4778916 (1988-10-01), Mita et al.
patent: 4780561 (1988-10-01), Mita et al.
patent: 5144073 (1992-09-01), Hubbs

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