2,4-diamino-3-hydroxycarboxylic acid derivatives

Details 2,4-diamino-3-hydroxycarboxylic acid derivatives 2,4-diamino-3-hydroxycarboxylic acid derivatives

1994-01-03

1996-07-23

Wu, Shean C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

564 57, A61K 3121, C07C27526

Patent

active

055389970

ABSTRACT:
The invention relates to compounds of formula I ##STR1## wherein the substituents have various significances. They can be prepared by conventional methods, e.g. coupling, substitution, deprotection or protection reactions.
They possess interesting pharmacological properties and are thus indicated for use in the treatment of retroviral infections, particularly as HIV proteinase inhibitors.

REFERENCES:
patent: 4661473 (1987-04-01), Boger et al.
J. Am. Chem. Soc. 1991, 113, 9382-9384.
J. Med. Chem. 1992, 35, 3080-3081.
Praeklinische Forschung (2 pages) 206th Am. Chem. Soc. Nat'l. Mtg. Aug. 22-27, 1993; Chicago
Antimicrobial Agents and Chemotherapy, Nov. 1991 p. 2209-2214.
Structure and Function of the Aspartic Proteinases and pp. 395-405.

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