Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-05-10
1993-11-16
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514376, 548110, 548117, 548235, 548236, A61K 3142
Patent
active
052625400
ABSTRACT:
Oxazole derivatives having Formula I or II are disclosed which are useful as inhibitors of mammalian blood platelet aggregation. ##STR1## Formula I and Formula XIX compounds are those wherein n is 7-9 and R is hydrogen or lower alkyl. Formula II compounds are those wherein R is hydrogen, lower alkyl or together with CO.sub.2 is tetrazol-1-yl; R.sub.1 is phenyl or thienyl; X is a divalent connecting group selected from the group consisting of CH.sub.2 CH.sub.2, CH.dbd.CH, and CH.sub.2 O; Y is a divalent connecting group attached to the 3 or 4 phenyl position selected from the group consisting of OCH.sub.2, CH.sub.2 CH.sub.2 and CH.dbd.CH. Formula XX compounds are those wherein the OCH.sub.2 CO.sub.2 R moiety is attached to the 3 or 4 phenyl position and R is hydrogen or lower alkyl.
REFERENCES:
patent: 3578671 (1971-05-01), Brown et al.
patent: 4391814 (1983-07-01), Vorbruggen
patent: 4460598 (1984-07-01), Lautenschlager et al.
patent: 4735961 (1988-04-01), Baldwin et al.
patent: 4775674 (1988-10-01), Meanwell et al.
patent: 4826990 (1989-05-01), Musser et al.
patent: 4925861 (1990-05-01), Hayashi et al.
patent: 5187188 (1993-02-01), Meanwell
Aldous et al. J. Org. Chem., 25:1151 (1960).
Pridgen et al., Tetrahedron Lett. vol. 25, No. 7, pp. 2835-2838 (1984).
Brown et al. Nature vol. 219, Jul. 13, 1966 p. 164.
Meanwell et al. J. Med Chem. 35 389-97 (1992).
Meanwell et al. J. Med. Chem. 35 3483-97 (1992).
Meanwell et al. J. Med. Chem. 35 3498-3512 (1992).
Bristol--Myers Squibb Company
Daus Donald G.
Kaye Michelle A.
Uloth Robert H.
LandOfFree
[2(4,5-diaryl-2 oxazoyl substituted phenoxy alkanoic acid and es does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with [2(4,5-diaryl-2 oxazoyl substituted phenoxy alkanoic acid and es, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and [2(4,5-diaryl-2 oxazoyl substituted phenoxy alkanoic acid and es will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-23563