Use of kunitz type plasma kallikrein inhibitors

Details Use of kunitz type plasma kallikrein inhibitors Use of kunitz type plasma kallikrein inhibitors

1995-06-05

1998-07-28

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, A61K 3857, C07K 1481

Patent

active

057863288

ABSTRACT:
Potent and specific serine protease inhibitors are provided that are capable of inhibiting plasma kallikrein. The inhibitors are provided in pharmaceutical compositions for the treatment of diseases and disorders where inhibition of plasma kallikrein in indicated.

REFERENCES:
patent: 4894436 (1990-01-01), Auerswald et al.
patent: 5032573 (1991-07-01), Auerswald et al.
patent: 5118668 (1992-06-01), Auerswald et al.
patent: 5164482 (1992-11-01), Ebbers et al.
patent: 5223482 (1993-06-01), Schilling, Jr. et al.
patent: 5373090 (1994-12-01), Norris et al.
Hynes, T.R. et al.(Oct. 1990) "X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor" Biochem. 29(43):10018-10022.
Kido, H. et al.(Dec. 1988) "Kunitz-type protease inhibitor found in rat mast cells" J. Biol. Chem. 34:18104-18107.
Badimon et al., "Hirudin and Other Thrombin Inhibitors: Experimental Results and Potential Clinical Applications" TCM 1(6):261-267 (1991).
Beckmann, J. et al., "Preparation of chemically `mutated`aprotinin homologues by semisynthesis" European Journal of Biochemistry 176:675-682 (1988).
Bhoola, K.D. et al., "Bioregulation of Kinins: Kallikreins, Kininogens, and Kininases" Pharmacological Reviews 44(1):1-80 (1992).
Bigler et al., "Binding of amino acid side chains to preformed cavities: Interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues" Protein Science 2:786-799 (1993).
Bode et al., "The refined 2.2-Angstrom (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg.sup.15 analogue of bovine pancrealic trypsin inhibitor" European Journal of Biochemistry 144:185-190 (1984).
Bode, W. et al., "Natural protein proteinase inhibitors and their interaction with proteinases" European Journal of Biochemistry 204:433-451 (1992).
Bone, R.C., "Modulators of Coagulation: A Critical Appraisal of Their Role In Sopsis" Arch Intern Med 152:1381-1389 (1992).
Castro et al., "Does the Kunitz domain from the Alzheimer's amyloid Beta protein precursor inhibit a kallikrein responsible for post-translational processing of nerve growth factor precursor?" FEBS 08591 267(2):207-212 (1990).
Chabbat et al., "Aprotinin Is A Competitive Inhibitor Of The Factor Vila-Tissue Factor Complex" Thrombosis Research 71:205-215 (1993).
Chu et al., "Mosaic structure of globular domains in the human type VI collagen .alpha. 3 chain: similarity to von Willebrand Factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors" EMBO Journal 9(2):385-393 (1990).
Creasey et al., "Tissue Factor Pathway Inhibitor Reduces Mortality from Escherichia coli Septic Shock" J. Clin. Invest. 91:2850-2860 (1993).
Creighton et al., "Biosynthesis, Processing, and Evolution of Bovine Pancreatic Trypsin Inhibitor" Cold Spring Harbor Symp Quant Biol 52:511-519 (1987).
Cronlund et al., "A Low Molecular Weight Platelet Inhibitor of Factor Xia: Purification, Characterization, and Possible Role in Blood Coagulation" Biochemistry 31:1685-1694 (1992).
Davie et al., "The Coagulation Cascade: Initiation, Maintenance, and Regulation" Biochemistry 30(43):10363-10370 (1991).
De Maeyer, M. et al., "Recombinant Kunitz Inhibitors of Coagulation Proteases. II. Random Mutagenesis" Thrombosis and Haemostasis (abstract 1245) 69(6):888 (1993).
Dennis et al., "Kunitz Domain Inhibitors of Tissue Factor-Factor VIIa; I. Potent Inhibitors Selected from Libraries by Phage Display" Journal of Biological Chemistry 269(35):22129-22136 (1994).
Dennis et al., "Kunitz Domain Inhibitors of Tissue Factor-Factor VIIa; II. Potent and Specific Inhibitors by Competitive Phage Selection" Journal of Biological Chemistry 269(35):22137-22144 (1994).
Eigenbrot, C. et al., "Structural Effects Induced by Mutagenesis Affected by Crystal Packaging Factors: The Structure of a 30-51 Disulfide Mutant of Basic Pancreatic Trypsin Inhibitor" Proteins: Structure, Function, and Genetics 14:75-87 (1992).
Eigenbrot, C. et al., "Structural effects induced by removal of a disulfide-bridge: The X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 Angstrom" Protein Engineering 3(7):591-598 (1990).
Fritz et al., "Biochemistry and Applications of Aprotinin, the Kallikrein Inhibitor from Bovine Organs" Arzneimittel-Forschung/Drug Research 33:479-494 (1983).
Fuhrer, C. et al., "Aprotinin in cardiopulmonary bypass--effects on the Hageman factor (FXII)-Kallikrein system and blood loss" Blood Coagulation and Fibrinolysis 3:99-104 (1992).
Girard et al., "Functional significance of the Kunitz type inhibitory domains of lipoprotein-associated coagulation inhibitor" Nature 338:518-520 (1989).
Girard et al., "Inhibition of Factor VIIa-Tissue Factor Coagulation Activity by a Hybrid Protein" Science 248:1421-1424 (1990).
Greer, "Comparative Modeling Methods: Application to the Family of the Mammalian Serine Proteases" Proteins: Struct. Funct. Genet. 7:317-334 (1990).
Hamamoto et al., "Inhibitory Properties of Full-length and Truncated Recombinant Tissue Factor Pathway Inhibitor (TFPI)" Journal of Biological Chemistry 268(12):8704-8710 (1993).
Haskel et al., "Prevention of Arterial Reocclusion After Thrombolysis With Recombinant Lipoprotein-Associated Coagulation Inhibitor" Circulation 84:821-827 (1991).
Holst et al., "Antithrombotic Properties of a Truncated Recombinant Tissue Factor Pathway Inhibitor in an Experimental Venous Thrombosis Model" Haemostasis 23(Suppl. 1):112-117 (1993).
Hynes et al., "X-ray Crystal Structure of the Protease Inhibitor Domain of Alzheimer's Amyloid .beta.-Protein Precursor" Biochemistry 29:10018-10022 (1990).
Katori, M. et al., "Evidence for the involvement of a plasma kallikrein-kinin system in the immediate hypotension produced by endotoxin in anaesthetized rats" Br. J. Pharmacol. 98:1383-1391 (1989).
Kido et al., "Protease-Specificity of Kunitz Inhibitor Domain of Alzheimer's Disease Amyloid Protein Precursor" Biochem. & Biophys. Res. Comm. 167(2):716-721 (1990).
Kitchens et al., "Factor XI: A Review of Its Biochemistry and Deficiency" Sem. in Thrombosis and Hemostasis 17(1):55-72 (1991).
Kossiakoff et al., "Molecular recognition in biological systems: From activation to inhibition" Bio. Society Transactions 21:614-618 (1993).
Laskowski et al., "Protein Inhibitors of Protinases" Ann. Rev. Biochem. 49:593-626 (1980).
Lawson et al., "Complex-dependent Inhibition of Factor VIIa by Antithrombin III and Heparin" Journal of Biological Chemisry 268(2):767-770 (1993).
Mann, Kenneth G., "Correspondence -Response" Blood 82:1680-1681 (1993).
Marks et al., "Mutants of Bovine Pancreatic Trypsin Inhibitor Lacking Cysteines 14 and 38 Can Fold Properly" Science 235:1370-1373 (1987).
McGrath et al., "The Sequence and Reactive Site of Ecotin" Journal of Biological Chemistry 266(10):6620-6625 (1991).
Nordfang et al., "The C-Terminus of Tissue Factor Pathway Inhibitor is Essential to Its Anticoagulant Activity" Biochemistry 30:10371-10376 (1991).
Patston et al., "Reactivity of .alpha. 1-Antitrypsin Mutants against Protcolytic Enzymes of the Kallikrein-Kinin, Complement, and Fibrinolytic Systems" Journal of Biological Chemistry 265(18):10786-10791 (1990).
Perona and Craik, "Structural basis of substrate specificity in the serine proteases" Protein Science 4:337-360 (1995).
Perona et al., "Crystal Structures of Rat Anionic Trypsin Complexed with the Protein Inhibitors APPI and BPTI" J. Mol. Biol. 230:919-933 (1993).
Petersen et al., "Characterization of Human Tissue Factor Pathway Inhibitor Variants Expressed in Saccharomyces cerevisiae" Journal of Biological Chemistry 268:13344 13351 (1993).
Rao et al., "Binding of Factor VIIa to Tissue Factor Permits Rapid Antithrombin III/Heparin Inhibition of Factor VIIa" Blood 81(10):2600-2607 (1993).
Roberts et al., "Directed evolution of a protein: Selection of potent neutrophil clastase inhibitors displayed on M13 fusion phage " Proc. Natl. Acad. Sci. USA 89:2429-2433 (1992).
Royston, D., "The serine antiprotease aprotinin (Trasylol.TM.): a novel approach to reducing postoperative

Affiliated with

Also associated with

Rating

Use of kunitz type plasma kallikrein inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of kunitz type plasma kallikrein inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of kunitz type plasma kallikrein inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-23564