Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1991-10-29
1993-11-02
Rollins, John W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
536 2532, 536 2534, C07F 900
Patent
active
052585387
ABSTRACT:
The compounds of the invention include novel linking agents comprising 2-substituted-3-protected-1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The compounds of the invention further include conjugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.
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Fung Steven
Smith Lloyd M.
Woo Sam L.
Applied Biosystems Inc.
Crane L. Eric
Dehlinger Peter
Macevicz Stephen C.
Rollins John W.
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