Administration of pharmaceutical agents

Details Administration of pharmaceutical agents Administration of pharmaceutical agents

1990-11-28

1993-07-20

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514356, 514456, A61K 3578, A61K 3144, A61K 3135

Patent

active

052291162

ABSTRACT:
The bioavailability of pharmaceutical agents susceptible to oxidation of cytochrome P-450, particularly anti-hypertensive dihydropyridines such as felodopine or nifedipine can be increased by administering, before, during or after the administration of the pharmaceutical agent, a flavonoid in the aglycone or glycoside form. This conjoint administration has the effect of prolonging the bioavailability of and so reducing the amount of pharmaceutical agent that needs to be administered. Grapefruit juice has been found to be a suitable source of the flavonoid.

REFERENCES:
patent: 3352754 (1967-11-01), Gazave
patent: 4707360 (1987-11-01), Brasey
patent: 4885305 (1989-12-01), Kiechel et al.

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