Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-06-28
1998-08-11
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549467, A61K 3134, C07D30781
Patent
active
057927910
ABSTRACT:
Disclosed are a 2,3-dihydrobenzofuran derivative represented by formula (1) or a salt thereof, a method for producing the same, and use thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; n is an integer of from 2 to 6; A represents a carbonyl group or a sulfonyl group; R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl group (which is unsubstituted or substituted with at least one halogen atom), a lower alkoxy group, a hydroxyl group, a nitro group or a cyano group; and * represents an asymmetric carbon atom.
A 2,3-dihydrobenzofuran derivative of the present invention or a salt thereof has a strong affinity for a serotonin 1A receptor, and, therefore, is useful for prevention and treatment of serotonergic neuron-related diseases, such as anxiety, depression, high blood pressure, emeses (including emeses induced by motion sickness, space sickness and dizziness, etc.) and the like.
REFERENCES:
patent: 4847254 (1989-07-01), Boegesoe et al.
patent: 5134140 (1992-07-01), Stack
patent: 5286735 (1994-02-01), Bonnaud et al.
Kogami Yuji
Mochizuki Daisuke
Asahi Kasei Kogyo Kabushiki Kaisha
Dentz Bernard
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