Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-28
2007-08-28
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S278000, C548S218000, C546S017000
Reexamination Certificate
active
10530429
ABSTRACT:
The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula:wherein R1represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2represents a group —OR3or the like, and R3represents a hydrogen atom, C1-C6 alkyl group or the like, or R1and —(CH2)nR2may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H):wherein R41is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action againstMycobacterium tuberculosis, multi-drug-resistantMycobacterium tuberculosis, and atypical acid-fast bacteria.
REFERENCES:
patent: WO97/01562 (1997-01-01), None
Sehgal et al., “Potential Radiosensitizing Agents. 2. Synthesis and Biological Activity of Derivatives of Dinitroimidazole With Oxiranes”; Journal of Medicinal Chemistry, vol. 24, No. 5, pp. 601-604, (1981).
Ashtekar et al.; “In Vitro and In Vivo Activities of the Nitroimidazole CGI 17341 AgainstMycobacterium tuberculosis”; Antimicrobial Agents and Chemotherapy, vol. 37, No. 2, pp. 183-186, (1993).
Nagarajan et al.; “Nitroimidazoles XXI 2,3-Dihydro-6-Nitroimidazo [2,1-b] Oxazoles With Antitubercular Activity”; European Journal of Medicinal Chemistry, vol. 24, No. 6, pp. 631-633, (1989).
Haraguchi Yoshikazu
Hasegawa Takeshi
Hashizume Hiroyuki
Itotani Motohiro
Kawasaki Masanori
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Nolan Jason M
Otsuka Pharmaceutical Co. Ltd.
Saeed Kamal A.
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