2,3,4-substituted cyclopentanones as therapeutic agents

Details 2,3,4-substituted cyclopentanones as therapeutic agents 2,3,4-substituted cyclopentanones as therapeutic agents

2006-09-05

2006-09-05

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S058000

Reexamination Certificate

active

07101906

ABSTRACT:
Disclosed herein are compounds comprisingor a pharmaceutically acceptable salt or a prodrug thereof,wherein a dashed line represents the presence or absence of a bond;Y is a carboxylic acid, sulfonic acid, or phosphonic acid functional group; or an amide or ester thereof comprising from 0 to 12 carbon atoms; or Y is hydroxymethyl or an ether thereof comprising from 0 to 12 carbon atoms; or Y is a tetrazolyl functional group;A is —(CH2)6—, cis —CH2—CH═CH—(CH2)3—, or —CH2—C≡C—(CH2)3— wherein 1 or 2 carbons may be substituted with S or O;B is hydrogen, C1-6hydrocarbyl, CN, CO2H, or —(CH2)mX(CH2)pH, wherein m is at least 1 and the sum of m and p is from 1 to 5;X is S or O;J is H, CH3, or CF3;D is a covalent bond, CH2, O, or S; andE is an aromatic heterobicyclic ring system which may have substituents comprising up to 6 non-hydrogen atoms each.Methods, compositions, and medicaments related thereto are also disclosed.

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