2-(2-Furoyl)-4-methylpyridine and its methyl iodide quaternary s

Details 2-(2-Furoyl)-4-methylpyridine and its methyl iodide quaternary s 2-(2-Furoyl)-4-methylpyridine and its methyl iodide quaternary s

1978-10-06

1979-11-06

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424263, C07D40502

Patent

active

041737059

ABSTRACT:
2-Cyano-4-methylpyridine is reacted in an inert atmosphere with an ethereal solution of freshly prepared 2-furoyl-lithium followed by acid hydrolysis to form 2-(2-furoyl)-4-methylpyridine which is then reacted with methyl iodide to form 2-(2-furoyl)-1,4-dimethylpyridinium iodide. Both furoyl compounds exhibit thermal and chemical analgesic properties.

REFERENCES:
Klingsberg, Pyridine and Its Derivatives, Part Two, pp. 2 to 6, 171 to 172, Interscience Publishers, Inc. NY (1961).
Riberau et al., C.R. Acad. Sc., Series C, vol. 280, pp. 293 to 296 (1975).
Berg et al., Chem. Abstracts vol. 72, Abst. No. 55273h (Abst. of So. Afr. 68 00,346) (1970).
Zelinski et al., J. Am. Chem. Soc., vol. 73, pp. 696 to 697 (1951).
Klingsberg, Pyridine and Its Derivatives, Part Four, pp. 152-154 and 217, Interscience Publishers, NY (1964).

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