2,2-Difluoro-16-phenoxy-13,14 dihydro-PGE, analogs

Details 2,2-Difluoro-16-phenoxy-13,14 dihydro-PGE, analogs 2,2-Difluoro-16-phenoxy-13,14 dihydro-PGE, analogs

1976-09-17

1977-12-20

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260520B, 260408, C07C 6522

Patent

active

040641600

ABSTRACT:
2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analog are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.

REFERENCES:
patent: 3775462 (1973-11-01), Axen

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