2,2-Alkyldiylbis(thio)bis(imidazoles)

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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548322, 548336, A61K 31415, C07D23384

Patent

active

041883977

ABSTRACT:
New 2,2'-alkyldiylbis(thio)bis(imidazoles) having substituted phenyl groups in the 4- and 5- positions of the imidazole rings are disclosed. These compounds regulate cell-mediated immunity and/or have anti-arthritic activity and are useful to relieve inflammation, for example in the treatment of rheumatoid arthritis.

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Gupta et al., Indian J. Chem., 1978, vol. 16B, pp. 329-331.
Johnson et al., J. Amer. Chem. Soc., 1942, vol. 64, pp. 2706-2708.
Ogura et al., Chem. Pharm. Bull., 1968, vol. 16(11), pp. 2167, 2168, 2170 & 2171.
Searle, J. Appl. Chem., (London), 1955, vol. 5, pp. 313-316.

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