1H-Cyclopenta[b]benzofuran derivative and its analog

Details 1H-Cyclopenta[b]benzofuran derivative and its analog 1H-Cyclopenta[b]benzofuran derivative and its analog

1983-10-14

1985-09-03

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564171, C07D30793, C07C103737

Patent

active

045394148

ABSTRACT:
Substantially pure compounds having the general formula ##STR1## wherein (1) ##STR2## R.sup.2 is .beta.-hydroxy and R.sup.3 and R.sup.4 together form an oxygen bridge, or (2) ##STR3## R.sup.2 and R.sup.3 together form an additional carbon-carbon bond, and R.sup.4 is hydroxy, are disclosed. These compounds exhibit antileukemic activity against P388 lymphocytic leukemia in CDF.sub.1 mice and inhibitory activity in vitro against cells derived from human epidermoid carcinoma of the nasopharynx(KB) cells.

REFERENCES:
King et al., J. Chem. Soc., Chem. Commun., vol. 20, pp.1150-1151, Oct. 15, 1982.
King et al., Journal of Medical Science, vol. 1, No. 1, pp. 11-20 (1975).

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