Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1992-12-01
1994-11-08
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 1286534, 514329, 514331, 514422, 514832, 546224, 546225, 546233, 548537, 548542, A61B 5055
Patent
active
053624777
ABSTRACT:
Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize .sup.19 F magnetic resonance contrast media having enhanced .sup.19 F relaxivity. Fluorine-containing compounds having enhanced .sup.19 F relaxation properties resulting from direct association with an unpaired spin are disclosed. The fluorine-containing compound is associated with the unpaired spin by covalent attachment of a stable free radical, by complexation of a fluorinated complexing agent with a paramagnetic metal ion, or by salt formation or charge neutralization of a paramagnetic ion.
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Adams Max D.
Cacheris William P.
deLearie Lynn A.
Moore Dennis A.
Periasamy Muthunadar P.
Hollinden Gary E.
Mallinckrodt Medical Inc.
Stierwalt Brian K.
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