17.beta.-substituted-6-azasteroid derivatives useful as 5.alpha.

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514253, 546 77, 546 78, 546 61, 544361, A61K 3149

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active

055167799

ABSTRACT:
Compounds of the formula ##STR1## are inhibitors of 5 .alpha.-reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, and benign prostatic hyperplasia.

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Diani, Jour Clin, Endo. & Metab. vol. 74 pp. 345-350 (1992).
J. Med. Chem., 6-Azasteroids; Potent Dual Inhibitors of Human Type 1 and 2 Steroid 5-Alpha-Reductase, Frye et al., 1993, vol. 36, 4313-4315.
G. Harris, et al., Pro. Natl. Acad. Sci., vol. 89, pp. 10787-10791, (1992).
C. D. Jones, et al., J. Med. Chem., vol. 36, pp. 421-423 (1993).
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