17 .alpha.-Dihydroequilin hapten and assay method

Details 17 .alpha.-Dihydroequilin hapten and assay method 17 .alpha.-Dihydroequilin hapten and assay method

1980-09-29

1983-04-12

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

2603974, 2603975, 260112B, 436823, 436817, 436822, 436804, 260112R, G01N 3354, G01N 3356, C07G 700, C07J 1300

Patent

active

043797806

ABSTRACT:
A hapten is obtained by replacing the 3-hydroxy group of 17 .alpha.-dihydroequilin with HO--CO--A--O-- wherein A is an alkylene of one to six carbon atoms. The hapten is conjugated with an immunological carrier to provide an immunogen, which in turn produces a specific antiserum to 17 .alpha.-dihydroequilin. The antiserum is used in a radioimmunoassay for 17 .alpha.-dihydroequilin.

REFERENCES:
patent: 4128629 (1978-12-01), Eldred et al.
patent: 4293536 (1981-10-01), Jensen et al.
LaBella et al., Chem. Abstracts, vol. 90, 1979, Abstract #66958h.
Rance et al., J. Steroid Biochem., vol. 9, 1978, pp. 1065-1069.
Rao et al., Steroids, vol. 29, 1977, pp. 461-469.
Whittaker et al., Lancet, vol. 1, 1980, pp. 14-16.
Morgan et al., J. Steroid Biochem., vol. 13, 1980, pp. 551-555.
Johnson et al., J. Pharm. Sci., vol. 67, 1978, pp. 1218-1224.
Rao et al., Ligand Quarterly, vol. 3, No. 1, 1980, p. 53.

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