16-hydroxyestratrienes as selectively active estrogens

Details 16-hydroxyestratrienes as selectively active estrogens 16-hydroxyestratrienes as selectively active estrogens

2006-09-19

2006-09-19

Qazi, Sabiha N. (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

C552S554000, C552S515000, C552S618000, C552S625000, C552S626000, C552S630000, C514S169000, C514S179000, C514S182000

Reexamination Certificate

active

07109360

ABSTRACT:
The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rather than the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds.The new compounds are 16α- and 16β-hydroxy-estra-1,3,5(10)-estratrienes, which carry additional substituents on the steroid skeleton and can have one or more additional double bonds in the B-, C- and/or D-rings.

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