16,17-acetalsubstituted pregnane 21-oic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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Other Related Categories

514177, 514463, 514826, 514859, 514861, 514863, 514886, 540 61, 540 70, A61K 3158, A61K 3156, A61K 31385, C07J 7100

Type

Patent

Status

active

Patent number

052159795

Description

ABSTRACT:
The invention refers to compounds having activity against inflammatory, allergic, and dermatological conditions. The compounds are characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula R.sub.1 is selected from a straight or branched hydrocarbon chain having 1-4 carbon atoms.
The invention also refers to processes for the preparation of these compounds, pharmaceutical preparations containing one of the compounds and a method for the treatment of inflammatory, allergic, muscoskeletal and dermatological conditions.

REFERENCES:
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patent: 3956347 (1976-05-01), Laurent et al.
patent: 4257969 (1981-03-01), Varma
R. Brattsand, et al., European Journal of Respiratory Diseases, Supp. No. 126, vol. 64, p. 513 (1983).
R. Brattsand, et al. and M. Willen et al., Microcirculation: Technical and Experimental, vol. 5 Nos. 2-3, Abstracts M-190 and M-191, p. 263 (1986).
R. Brattsand, et al in "Determinants of the lung-specific actions of Glucocorticosteroids," pp. 145-153 (1984).
C. G. A. Persson, Lung, vol. 166, pp. 1-23 (1988).
S. M. Laycock et al., International Journal of Allergy and Applied Immunology vol. 81, pp. 363-367 (1986).
S. M. Laycock et al., International Journal of Allergy and Applied Immunology vol. 82, pp. 347-348 (1987).
H. Smith, Pulmonary Pharmacology, vol. 2, pp. 59-74, 1989.
H. Laurent et al, "New Biologically Active Pregnan-21-OIC Acid Esters", I. Steroid Biochem. 6 (1975) pp. 185-192.
Goodman and Gilman's The Pharmacological Basis of Therpeutics, Seventh Edition, pp. 5-15, 21, 44-47, 1475, (1985).

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