16,17-acetalsubstituted pregnane 21-oic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514177, 514463, 514826, 514859, 514861, 514863, 514886, 540 61, 540 70, A61K 3158, A61K 3156, A61K 31385, C07J 7100

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active

052159795

ABSTRACT:
The invention refers to compounds having activity against inflammatory, allergic, and dermatological conditions. The compounds are characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula R.sub.1 is selected from a straight or branched hydrocarbon chain having 1-4 carbon atoms.
The invention also refers to processes for the preparation of these compounds, pharmaceutical preparations containing one of the compounds and a method for the treatment of inflammatory, allergic, muscoskeletal and dermatological conditions.

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H. Smith, Pulmonary Pharmacology, vol. 2, pp. 59-74, 1989.
H. Laurent et al, "New Biologically Active Pregnan-21-OIC Acid Esters", I. Steroid Biochem. 6 (1975) pp. 185-192.
Goodman and Gilman's The Pharmacological Basis of Therpeutics, Seventh Edition, pp. 5-15, 21, 44-47, 1475, (1985).

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