14-deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and phar

Details 14-deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and phar 14-deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and phar

1993-06-24

1996-02-06

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540102, 540107, 540108, C07D40512, A61K 31585

Patent

active

054895820

ABSTRACT:
14-Deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical compositions comprising same for treating cardiovascular disorders, such as heart failure and hypertension, are disclosed.

REFERENCES:
patent: 4259240 (1981-03-01), Miesner et al.
Stache, Tetrahedron Letters No. 42 pp. 3897-3880 (1971),
Donovan et al., Tetrahedron Letters No. 35, pp. 3287-3290 (1979).
Bobbio, J. Org. Chem 1961 vol. 26 (pp. 3023-3024).
Fritsch et al, Liebigs Ann. Chem 1966 pp. 195-205.
Kreiser et al, Liebigs Ann. Chem. 1972 pp. 12-16.
Erdman, Arzneim Forsch 1984 vol. 34 1314.
Naidoo et al, J. Pharm. Sciences 1974 vol. 63, pp. 1391-1394.
Jorgensen, Biochimica et Biophysica Acta 1974 356 pp. 36-52.

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