Certain N-octahydro-indolizinebenzamides and their use in treati

Details Certain N-octahydro-indolizinebenzamides and their use in treati Certain N-octahydro-indolizinebenzamides and their use in treati

1983-04-22

1985-12-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514309, 546112, 546143, 546146, 546150, A61K 31445, C07D47104

Patent

active

045593469

ABSTRACT:
A compound of formula (I), or a pharmaceutically acceptable salt, N-oxide or solvent adduct thereof: ##STR1## wherein: R.sub.1 is C.sub.1-6 alkoxy, C.sub.1-6 alkylthio or, together with R.sub.5 is C.sub.1-2 alkylene, and one of R.sub.2, R.sub.3 and R.sub.4 is hydrogen and the other two together are C.sub.1-2 alkylenedioxy, or the other two are the same or different and are selected from the class of hydrogen, halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-7 acyl, C.sub.1-7 acylamino, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkylsulphinyl hydroxy, nitro or amino, aminocarbonyl or aminosulphonyl optionally N-substituted by one or two C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, phenyl or phen C.sub.1-4 alkyl groups or optionally N-disubstituted by C.sub.4-5 polymethylene, or R.sub.1 and R.sub.2 together are C.sub.1-2 alkylenedioxy, and R.sub.3 and R.sub.4 together are C.sub.1-2 alkylenedioxy or R.sub.3 and R.sub.4 are the same or different and are selected from the previously defined class of substituents;

REFERENCES:
patent: 4391978 (1983-07-01), Imhof et al.
I. Claxton et al., "BRL 8242 (2-[2-Benzimidazolyl]-Amino-2-Imidazoline Dihydrochloride), A New Inhibitor of Dopamine-.beta.-Hydroxylase with Antihypertensive Activity", European Journal of Pharmacology, 37 (1976) 179-188.
G. Poulain, "Synthese des nitriles-aldehydes succinques .alpha.,.alpha.-disubstitues et transforation de ceux-ci en diacides, nitriles-acides et imides correspondants", Bull. Soc. Chim. Fr. 1964, 913.
P. Protais et al., "Climbing Behavior Induced by Apomorphine in Mice: A Simple Test for the Study of Dopamine Receptors in Striatum", Psychopharmacology, 50, 1-6 (1976).

Affiliated with

Also associated with

Rating

Certain N-octahydro-indolizinebenzamides and their use in treati does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain N-octahydro-indolizinebenzamides and their use in treati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain N-octahydro-indolizinebenzamides and their use in treati will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2175213