13-Norleucine-14-desamido motilin, a method for preparing it and

Details 13-Norleucine-14-desamido motilin, a method for preparing it and 13-Norleucine-14-desamido motilin, a method for preparing it and

1974-03-27

1976-08-31

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

039780350

ABSTRACT:
The specification describes the total synthesis of L-norleucine-13-motilin ased on the replacement of the L-methionine radical located in the 13-position by an L-norleucine radical. In accordance with the present day development of peptide synthesis the central arginyl-methionyl-bond (amino acids 12 and 13 of motilin) can in practice hardly be synthesised, while on the other hand the norleucine-13-docosapeptide corresponding to motilin can be more readily produced synthetically, and this provides for a comparatively rapid determination of structure and can give important information as regards the biological effect specificity of methionine.

REFERENCES:
brown et al., Can. J. Biochem., 51, 533-537 (1973).
Brown et al., Chem. Abstr. 76:150240m (1972).

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