11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-

Details 11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione 21- 11.beta., 17.alpha.,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-

1989-01-23

1991-05-14

Friedman, Stanley J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552559, A61K 3156

Patent

active

050157469

ABSTRACT:
11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.
11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.

REFERENCES:
patent: 3488421 (1970-01-01), Casadio
Chemical Abstracts, vol. 110, #33848a; Mizushima et al.
Chemical Abstracts, vol. 105 (1986) #203378p; Mizushima et al.
Chemical Abstracts; vol. 71 (1969) #61678q; Istituto DeAngeli.
Medicina, 22(7), p. 1174 (1985).
3rd Japan DDS Research Society Conference Program Preliminary Draft Report, p. 52 (1987).
8th Japanese Society of Inflammation Program Preliminary Draft Report, p. 90 (1987).
Mebio, 4(8), p. 78 (1987).
3rd Transdermal Therapeutic System Symposium Program, p. 4 (1987).
108th Pharmaceutical Society of Japan, p. 580 (1988).

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