11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E

Details 11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E 11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E

1992-03-24

1994-01-11

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514181, 552576, A61K 3156, C07J 500

Patent

active

052781569

ABSTRACT:
11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the formula ##STR1## an antiinflammatory composition thereof and a method for the production thereof.
11.beta.,17.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate] of the present invention exhibits remarkably excellent antiinflammatory action and besides, displays reduced side effects and can be produced in high selectivity and good yield and conveniently.

REFERENCES:
patent: 3488421 (1970-01-01), Casadio
Mizushima et al., Chemical Abstracts vol. 105(23):203,378p, 1986.
Igarashi et al., Chemical Abstracts vol. 110 (5) 33848a, 1988.
Instituto De Angli, (1969) Chemical Abstracts vol. 71 (13) 61678q, 1968.
"Biochemistry", Lehninger, Worth Publishers Inc. (pub) (1975) pp. 681-683.
"Organic Chemistry", Fessenden and Fessenden, Willard Grant Press (pub.) (1982) pp. 110-117.
Mori, K., "Yakugaku Zasshi", 102(10) 899-910 (1982).
Mori, K. "The Total Synthesis of Natural Products", 4, Chapter 1, pp. 1-4 and 168 (1981).
"Science", 192, 894-896 (May 28, 1976).
"Naturwissenschaften", 65 653-654 (1978).
"Science", 197, 789-792 (Aug. 19, 1977).
"Science", 192, 896-898 (May 28, 1976).
"Angewandte Chemie", 73 (11) 349-353 (1961) German language.
"Science", 181, 661-663 (Aug. 17, 1973).
Roelofs, W. L. et al., "J. Insect Physiol.," 17, 435-448 (1971).
"Science", 181, 873-875 (Aug. 31, 1973).
Medicina, 22(7), p. 1174 (1985).
3rd Japan DDS Research Society Conference Program Preliminary Draft Report, p. 52 (1987).
8th Japanese Society of Inflammation Program Preliminary Draft Report, p. 90 (1987).
Mebio, 4(8), p. 78 (1987).
3rd Transdermal Therapeutic System Symposium Program, p. 4 (1987).
Therapeutic Research, 8(1), p. 206 (1988).
108th Phramaceutical Society of Japan, p. 580 (1988).

Affiliated with

Also associated with

Rating

11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 11-beta, 17-alpha, 21-trihydroxy-1, 4-pregnadiene-3, 20 21-[(E-E will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1631398