1-Substituted-4-benzylpiperidines

Details 1-Substituted-4-benzylpiperidines 1-Substituted-4-benzylpiperidines

1974-12-11

1976-05-11

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029364, 26029369, 26029372, 26029374, 26029376, 26029377, 2602938, 26029384, 424248, 424267, C07D29500

Patent

active

039562964

ABSTRACT:
Novel 1-substituted-4-benzylpiperidines having .alpha.-substituents on the 4-benzyl moiety useful as antiinflammatory agents, sedatives, and tranquilizers are represented by the formula ##SPC1##
Wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkylcarbamoyl, N-lower-alkylcarbamoyl, N,N-dilower-alkylcarbamoyl, N-arylcarbamoyl, N-(.omega.-nitrogen containing heterocycle)lower-alkylcarbamoyl, N-(.omega.-aminolower-alkyl)carbamoyl, 2-hydroxy-3-(o-methoxyphenoxy)propyloxycarbamoyl, 2-carbamoylethyl, or 4-(p-fluorobenzoyl)piperidinoethyl; R.sup.1 represents hydrogen or hydroxy; R.sup.2 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R.sup.2 is phenyl, R is other than aroylloweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of Formula I are included as part of the invention.

REFERENCES:
patent: 2739968 (1956-03-01), Sperber et al.
patent: 2739969 (1956-03-01), Sperber et al.
patent: 3000896 (1961-09-01), Hoffmann et al.
patent: 3073835 (1963-01-01), Rorig
patent: 3576810 (1971-04-01), Duncan et al.
patent: 3806526 (1974-04-01), Carr et al.

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