1-oxyalkyl-2-carboxyl-7-nonsubstituted indole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S326000, C514S415000, C546S201000, C544S143000, C548S483000

Reexamination Certificate



Compounds of Formula Iwherein A1, B1, C1, D1, E1, F1and L1are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein, such as leukemia and lymphoma, are disclosed.

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