RhoB variants and methods of use

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S023500

Reexamination Certificate

active

07951924

ABSTRACT:
In one aspect, the present invention concerns RhoB variant polypeptides and isolated degenerate polynucleotides encoding the RhoB variant polypeptides. In another aspect, the present invention concerns nucleic acid constructs containing a polynucleotide encoding a RhoB variant polypeptide, and host cells genetically modified to express such polynucleotides. In another aspect, the present invention provides a method of inhibiting the growth of, and inducing apoptosis in, cancerous cells by contacting the cells with an effective amount of a RhoB variant.

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