1-N-(.omega.-aminoalkanesulfonyl) derivative of aminoglycosidic

Details 1-N-(.omega.-aminoalkanesulfonyl) derivative of aminoglycosidic 1-N-(.omega.-aminoalkanesulfonyl) derivative of aminoglycosidic

1978-06-01

1979-10-09

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 10, 536 17R, A61K 3171, C07H 1522

Patent

active

041706412

ABSTRACT:
A new 1-N-(.omega.-aminoalkanesulfonyl) derivative of an aminoglycosidic antibiotic such as ribostamycin, 3'-deoxy- or 3',4'-dideoxy-ribostamycin, kanamycin A or B, and 3'-deoxy- or 3',4'-dideoxy-kanamycin B exhibits a broader, antibacterial spectrum than the parent aminoglycosidic antibiotic and is useful in the therapeutic treatment of infections caused by gram-positive and gram-negative bacteria including drug-resistant strains thereof. The aforesaid derivative may be made by reaction between the parent antibiotic and an amino-protected .omega.-aminoalkanesulfonic acid halide and removal of the amino-protecting group from the condensation product.

REFERENCES:
patent: RE28647 (1975-12-01), Umezawa et al.
patent: 3268508 (1966-08-01), Sugazawa et al.
patent: 3925354 (1975-12-01), Umezawa et al.
patent: 3965089 (1976-06-01), Umezawa et al.

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