1- Methylcarbapenem derivatives

Details 1- Methylcarbapenem derivatives 1- Methylcarbapenem derivatives

1998-06-12

2000-07-18

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540350, A61K 31409, C07D47720

Patent

active

060908025

ABSTRACT:
A 1-methylcarbapenem compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 represents hydrogen or an ester residue; and A represents a group of the formula (A1) ##STR2## wherein n is 0, 1 or 2, P is 0, 1 or 2, R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sup.4 is a group (Q2) ##STR3## wherein B is phenylene, phenylene(C.sub.1 -C.sub.3)alkyl, cyclohexylene, cyclohexylene(C.sub.1 -C.sub.3)alkyl or C.sub.1 -C.sub.5 alkylene, R.sup.7 is hydrogen or C.sub.1 -C.sub.4 alkyl, and R.sup.14 is a group --C(.dbd.NH)R.sup.8, wherein R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl or a group --NR.sup.9 R.sup.10, wherein R.sup.9 and R.sup.10 are the same or different and are hydrogen or C.sub.1 -C.sub.4 alkyl; or a pharmacologically acceptable salt thereof.

REFERENCES:
patent: 5122604 (1992-06-01), Sunagawa et al.
patent: 5712267 (1998-01-01), Kawamoto
patent: 5977097 (1999-11-01), Kawamoto
Abstract for JP 11-71277 & translation thereof, Mar. 1999.
Hackh's Chemical Dictionary, 4th Edition (Grant, Ed) p. 35, 1969.

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