1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives

Details 1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives 1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives

1980-04-03

1982-01-12

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568807, 568379, 568380, 568664, 568669, 568670, 568816, 568838, 568822, 560231, 560 64, 560 65, 560 73, 560106, 560107, 424308, 424311, 424331, 424340, 424341, 424343, 424339, 568367, 568631, 568644, 568645, C07C 49597, C07C 3506

Patent

active

043107001

ABSTRACT:
Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

REFERENCES:
patent: 3873607 (1975-03-01), Bernady et al.
patent: 3931289 (1976-01-01), Bundy
patent: 3936487 (1976-02-01), Nelson
patent: 3944593 (1976-03-01), Nelson
patent: 3950406 (1976-04-01), Floyd et al.
patent: 3965143 (1976-06-01), Collins et al.
patent: 4061670 (1977-12-01), Floyd et al.
patent: 4212969 (1980-07-01), Wissner et al.
Bently, Chem. Soc. Rev., #2, pp. 29-70, (1973).

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