1-fluoro, 4-fluoro, and 1,4-difluoro-2'-halo anthracycline antib

Details 1-fluoro, 4-fluoro, and 1,4-difluoro-2'-halo anthracycline antib 1-fluoro, 4-fluoro, and 1,4-difluoro-2'-halo anthracycline antib

1985-03-20

1987-05-05

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 186, C07H 1524

Patent

active

046634452

ABSTRACT:
Anthracycline antibiotics represented by the formula (I) ##STR1## wherein R is hydrogen or hydroxyl, one of X and Y is fluorine and the other is hydrogen or both X and Y are fluorine, and S is a 2-halo sugar moiety; pharmaceutical preparations containing the same; and a method for inhibiting the growth of mammalian tumors are disclosed.

REFERENCES:
patent: 4125607 (1978-11-01), Arcamone et al.
patent: 4427664 (1984-01-01), Horton et al.
patent: 4472571 (1984-09-01), Fujiwara et al.

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