Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1983-06-27
1987-05-05
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 24, C07H 1920, C07H 19173
Patent
active
046634460
ABSTRACT:
New purine compounds having the formula: ##STR1## Y and Y'=H, ##STR2## X=H, alkyl, halo; ##STR3## A=O, S, NH.sub.2 are provided. These compounds are useful in treating patients having cancer, since they are potent and selective inhibitors of replicative DNA synthesis in mammalian cells since they inhibit DNA polymerase .alpha..
New purine compounds also are provided having the formula: ##STR4## wherein Y, A, Z are as defined above, X'=C.sub.2 H.sub.5 Y"=--CH.sub.3 or ##STR5## These compounds are useful to prevent bacterial growth since they are potent inhibitors of DNA polymerase III.
New Purine compounds also are provided having the formula: ##STR6## wherein Z' is H, OH or CH.sub.2 OH,
REFERENCES:
patent: 3480613 (1969-11-01), Walton
patent: 3936439 (1976-02-01), Marumoto et al.
patent: 4267171 (1981-05-01), Bergstrom et al.
Gutorou et al., Amino Purines, Chem Abstracts 91: 108007a (1979).
Wright et al., Butylanilinouracil: A Selective Inhibiter of . . . HeLa Cell DNA Polymerase Alpha, Chem Abstracts 92:123967c (1980).
Nishimura et al., Optical Rotary Dispension of the Anomeric Nucleosides and Nucleotides, Biochem Biophys Acta 157, B pp. 221-232 (1968).
Bauer, Laboratory Studies on Acyclovir, Chem Abstracts 94:167716r (1980).
St. Clair et al., Inhibition of Cellular Alpha and Virally Induced DNA Polymerases by the Triphosphate of Acyclovir, Chem Abstracts 94:26701v (1980).
Wright et al., Inhibitors of B. Subtilis DNA Polymerase III, 6-Anilinouracils and 6-(Alkylamino)uracils, J Med Chem 23, pp. 34-38 (1980).
Wright et al., Design and Characterization of N.sup.2 -Arylaminopurines Which Selectively Inhibit . . . Replication-Specific DNA Polymerases . . . , Nucleic Acids Research 10, pp. 4431-4440 (7/24/82) (1982).
Brown et al., Inhibitors of B. Subtilis DNA Polymerases III . . . 6-Anilinouracils, Chem Abstracts 87: 194650b (1977).
Rochowska et al., Inhibitions of Calf Thymus DNA Polymerase Alpha of . . . Cancer Cell Growth by Butylanilinouracil and Butylphenylguanine, Chem Abs 98:245g (1982).
Brown Johnnie R.
Cook Paul J.
Trustees of the Univ. of Massachusetts
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